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The film begins in the fall of 2009 on an interview talking about the cure rate from the new krippen drug. In September 2012, U.S. Army virologist Lieutenant Colonel Robert Neville (Will Smith) is left as the last healthy human in New York City. Three years earlier, a cure for cancer made from a re-engineered measles virus was developed with a 100% success rate. However, the virus mutated into a lethal strain that spread worldwide and killed 5.4 billion people (90% of humanity). Of the 600 million survivors, only 12 million people were naturally immune to the virus. The rest degenerated into bald, pale, aggressive beings referred to as Darkseekers, who hunted down the immune humans as prey. The Darkseekers are so-called for hiding in buildings and dark places during the day due to a painful intolerance to UV radiation. The infected exhibit increased speed, agility, aggression, and strength. These abilities stem from an increased metabolic rate, which also consumes the infected with an overwhelming hunger which makes them resort to cannibalism. Despite their primal behavior, the Darkseekers seem to retain some basic problem-solving intelligence, animalistic cunning, and the capacity to organize themselves.